That's awesome! I happen to be from around that area, so it's weird to think that visiting a place that's normal to me is a special occasion for someone else. New York City can be overwhelming and kind of scary, but it's certainly manageable once you get used to it. I should give you some useful advice for once you enter New York City. What I'm about to say is gonna sound cynical, but it's very important that you know all of this, so please be sure to read it very carefully.
Once you're in NYC, the first thing you should do is get a Metrocard and store a good amount of money on it, if you haven't already. That will allow you access to all of the public transportation in the city, which is important because NYC's pretty big! Trust me, you'll want to use public transportation because going everywhere by foot is the easiest way to exhaust yourself. I prefer using the subway system because it's faster, but there's buses and taxis driving around the city, too. The city itself is set up like a grid so it's actually quite simple to navigate around it. Also, be sure to get your Metrocard from the underground machines near the subways and only from there because it's actually illegal to sell the cards yourself, so if someone offers to sell you one then they're trying to trick you.
Actually, if any stranger comes up to you on the street (as in, they're the ones who initiate the conversation) and offers to sell you something or flat out asks for money, don't give in to your kinder nature and accept because it's usually a trick to swindle you out of money or personal information. Those kinds of people usually target tourists and younger people because they don't know any better, so be very careful. Also be on the lookout for people who pickpocket! They don't make themselves obvious, so anyone who brushes against you in a crowd and says, "oh, sorry" could easily do it without you realizing until it's too late. It's impossible to stop them outright, but you can make it more difficult for them if they do decide to target you. I suggest spreading your on-hand money between different pockets (so if they take money from one pocket, they aren't taking all of it), wearing your carry-on bag tightly to your body and with the bag part of the bag over your front rather than your back, using zipped pockets, having a cheap "decoy" wallet with only a couple of single-dollar bills or Monopoly money (yes, really) while your actual wallet is more well-hidden, etc. This is why people aren't as outgoing, friendly, or trusting in NYC compared to other places; everyone's trying to trick you until they prove otherwise. I know it's not a pleasant thought, but you really do need to keep your guard up at all times, lest you leave the city empty-handed.
If you can, make sure to bring your own food and water bottle because food in NYC usually costs an arm and a leg, especially in the museum's cafes. If your water bottle is empty, you can refill it at a water fountain for free instead of buying a whole new bottle (trust me, you'll flip once you see how much a water bottle costs). They even have water fountains shaped like tiny sink faucets meant for refilling water bottles instead of drinking from them directly, but no one will really point them out because it shouldn't cost anything to use them.
One last thing: I know the buildings are big and tall and impressive-looking, but don't spend too much time looking up at them. I know that sounds kind of silly, but doing that is no better than wearing a big, flashing neon sign that says, "HEY, LOOK, EVERYONE! I'M A TOURIST!" and keeping in mind what I told you about how swindlers usually target tourists, that's kinda not the vibe you'll want to give off.
On a lighter note, as much as I love Nintendo NY, be sure to keep your expectations in check as far as its size goes since, as cool as it is and as much as I love the video game stands and exhibits (especially the massive screen that's upstairs where you can play the latest games), it's actually quite small. It's sort of disappointing when you compare its size to the nearby M&M's and LEGO stores, but it doesn't make it any less awesome to be there. Just don't go in expecting a huge theme park! It's definitely a store, but it's one of the coolest stores you could ever shop and play games in if you're a fan of Nintendo! They have tons of Amiibos, rare games (I actually bought Fire Emblem: Radiant Dawn on the Wii from there, no strings attached), plush toys, tee-shirts, and it's even the home of that one Game Boy which was caught in the Gulf War and still works.
You should also visit Chinatown if you get the chance. It's almost like being in a different city there. There's a lot of Asian markets, and they have some of the best food that's actually worth the asking price. If you've ever wanted to visit Japan or any other Asian city but can't actually go to one, Chinatown's probably the next best thing.